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Recombinant Human LIGHT/TNFSF14(His Tag)

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翌圣生物科技(上海)股份有限公司更新時(shí)間：2024-12-24 09:03:45

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產(chǎn)品信息

產(chǎn)品名稱	產(chǎn)品編號(hào)	規(guī)格
Recombinant Human LIGHT / TNFSF14	93747ES25	25 μg
	93747ES60	100 μg
	93747ES76	500 μg

產(chǎn)品描述

LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. LIGHT is an acronym which stands for "is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes". LIGHT has also been called HVEM-L and LT-gamma. Under the new TNF nomenclature, it is called TNFSF14. LIGHT is a 240 amino acid (aa) protein that contains a 37 aa cytoplasmic domain, a 22 aa transmembrane region, and a 181 aa extracellular domain. LIGHT overexpression in tumor cells induces apoptosis, which can be enhanced by IFN-gamma. The full roles of LIGHT remain to be elucidated.

產(chǎn)品性質(zhì)

別名（Synonyms）	CD258, TNFSF14, HVEM-L, LIGHT, LTg, TR2
Uniprot No.	O43557-1
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）	HEK293 Cells-derived Human LIGHT / TNFSF14 Protein, Asp74-Val240 with hFc tag at the N-terminal
分子量(Molecular Weight)	Approximately 19 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result.
外觀(Physical Appearance）	Sterile Filtered White lyophilized (freeze-dried) powder.
純度（Purity）	> 95% as determined by SDS-PAGE and HPLC
活性（Activity）	1.ELISA Data: Immobilized Human LIGHT, His Tag at 1 μg/mL (100 μL/Well) on the plate. Dose response curve for Human HVEM, hFc Tag with the EC₅₀ of 0.12 μg/mL determined by ELISA. 2.ELISA Data: Immobilized Human LIGHT, His Tag at 0.5 μg/ml (100 μL/Well) on the plate. Dose response curve for Human LTBR, hFc Tag with the EC₅₀ of 22.9 ng/mL determined by ELISA.
內(nèi)毒素（Endotoxin）	< 1.0 EU per 1μg of the protein by the LAL method.
制劑（Formulation）	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
復(fù)溶（Reconstitution）	Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL` is recommended (usually we use 1mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.